Distal CpG islands can serve as alternative promoters to transcribe genes with silenced proximal promoters
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چکیده
منابع مشابه
Distal CpG islands can serve as alternative promoters to transcribe genes with silenced proximal promoters.
DNA methylation at the promoter of a gene is presumed to render it silent, yet a sizable fraction of genes with methylated proximal promoters exhibit elevated expression. Here, we show, through extensive analysis of the methylome and transcriptome in 34 tissues, that in many such cases, transcription is initiated by a distal upstream CpG island (CGI) located several kilobases away that function...
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ژورنال
عنوان ژورنال: Genome Research
سال: 2017
ISSN: 1088-9051,1549-5469
DOI: 10.1101/gr.212050.116